EFSA’s peer review of glyphosate’s risk assessment did not raise any critical concerns regarding its impact on human health, animals, and the environment. However, there are some data gaps that need further consideration during the renewal process. In a hazard assessment conducted by the European Chemicals Agency (ECHA), glyphosate was found not to meet the criteria for being classified as a carcinogenic, mutagenic, or reprotoxic substance. Data gaps and outstanding issues were reported in EFSA’s conclusions, including the assessment of impurities, dietary risks, risks to aquatic plants, and toxicity information of components in the glyphosate-based pesticide formulation. The assessment also highlighted complex risks to biodiversity and high long-term risks to mammals in certain glyphosate uses. The overall process involved extensive scientific evaluation and input from stakeholders, ensuring transparency. Glyphosate’s use in Europe is subject to strict regulation, and its approval is currently valid until December 15, 2023. More